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n.
condition in which there is a disturbance of normal functioning; "the doctor prescribed some medicine for the disorder"; "everyone gets stomach upsets from time to time"
n.
a condition or state of affairs almost beyond one's ability to deal with and requiring great effort to bear or overcome; "grappling with financial difficulties"
n.
an annoying or frustrating or catastrophic event; "his mother-in-law's visits were a great trial for him"; "life is full of tribulations"; "a visitation of the plague"
n.
a serious (sometimes fatal) infection of rodents caused by Yersinia pestis and accidentally transmitted to humans by the bite of a flea that has bitten an infected animal